New research indicates that people who stop using blockbuster GLP-1 drugs like Mounjaro or Wegovy can put back on reduced body mass much more quickly than those who stop traditional diet and exercise programs.
Findings released in a major medical journal points out that while obese people can lose a large proportion of their body weight while using the jabs, the weight comes back at an average rate of nearly a kilo each month once they quit.
"People using these treatments should be informed of the danger of quick weight regain when the medication concludes," warns researcher Dr. Susan Jebb.
This pace of regain suggests a reversion to pre-treatment weight in about 18 months.
Analyzing Treatments
The study, which reviewed 37 of studies involving over 9,000 of participants, contrasted the effects of the injectable medications with other pills.
Researchers note that people who shed pounds through diet and exercise generally see a less rapid creep back—perhaps 0.1 kg a month—after stopping.
Explaining the Fast Regain
Experts propose the mechanism of the jabs explains the heightened weight return.
These medications mimic a body's own chemical called GLP-1, which moderates hunger.
"Long-term administration of GLP-1 levels several times higher than the body's typical production might result in the body to produce less of its own natural hormone, and could diminish sensitivity to its effects," said Dr. Adam Collins, a nutrition expert.
"Withdrawal of this hormone supplement means appetite is unsuppressed, making binge eating much more probable."
A Chronic Disease?
Health authorities recommend the jabs for individuals with obesity-related medical conditions, alongside recommended lifestyle changes.
A number of clinicians argue that, given the likelihood of weight regain, the therapy might need to be long-term.
This perspective is echoed by pharmaceutical companies, who state that the findings "highlight the persistent character of excess weight," similar to managing conditions like hypertension.
User Accounts
Individuals who have come off the jabs report a powerful resurgence of hunger.
"It was like something flipping and you become ravenous," recalled a patient.
This challenge is exacerbated if patients have not adopted permanent lifestyle or habit modifications during therapy.
Widespread Use
Figures suggest that millions of people in the UK have tried weight-loss jabs in the past year, with desire remaining high.
- Adoption is higher among females compared to males.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion access the medications through private healthcare rather than the NHS.
Finally, researchers emphasize that while the jabs are potent agents for shedding pounds, they are not a magic cure and maintained weight loss relies on integrated behavioural management.
